SARS-CoV-2 Spike Protein RBD (L452R Mutation) | abx620007

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  • SARS-CoV-2 Spike Protein RBD (L452R Mutation)
  • SARS-CoV-2 Spike Protein RBD (L452R Mutation)
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Description

SARS-CoV-2 Spike Protein RBD (L452R Mutation). Cat# abx620007. Supplier: abbexa.

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2/COVID-19) Spike Protein Receptor-Binding Domain (RBD) is a recombinant protein expressed in Mammalian cells.

The SARS-CoV-2 Spike Protein (S protein) is a viral protein that allows the entry of SARS-CoV-2 into human cells. The protein forms trimers on the viral capsid and binds to human Angiotensin Converting Enzyme 2 (ACE2) located on the cell surface. The protein has a cleavage site between the Spike Protein and S2 subunits that is targeted by the human enzyme Furin, and it may also cause the development of a syncytium (cell fusion). Antibodies to S protein can prevent viral entry as well as target the virus for further immune action.

 

The L452R mutation is present in the B.1.429/B.1.427 (CAL.20C/Epsilon) variant first identified in California, USA.

Target Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Spike Protein RBD (L452R Mutation)
Target Modification Leu452Arg
Modification Mutation
Origin Virus
Expression Recombinant
Host Mammalian cells
Recommended dilutions Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Form Lyophilized
Purity > 90% (SDS-PAGE)
Reconstitution Reconstitute in ddH2O to a concentration of 1 mg/ml.
Storage Store between -20 °C and -80 °C. Avoid repeated freeze/thaw cycles.
NCBI Accession YP_009724390.1
Molecular Weight Observed MW: 35 kDa
Tag C-terminal His tag
Buffer Prior to lyophilization: PBS, pH 7.5.
Availability Shipped within 5-10 working days.
Note This product is for research use only.
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