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SARS-CoV-2 Spike Protein RBD (S477N Mutation) | abx620008
- SKU:
- abx620008
- Availability:
- Usually shipped in 5 working days
Description
SARS-CoV-2 Spike Protein RBD (S477N Mutation). Cat# abx620008. Supplier: abbexa.
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2/COVID-19) Spike Protein Receptor-Binding Domain (RBD) is a recombinant protein expressed in Mammalian cells.
The SARS-CoV-2 Spike Protein (S protein) is a viral protein that allows the entry of SARS-CoV-2 into human cells. The protein forms trimers on the viral capsid and binds to human Angiotensin Converting Enzyme 2 (ACE2) located on the cell surface. The protein has a cleavage site between the Spike Protein and S2 subunits that is targeted by the human enzyme Furin, and it may also cause the development of a syncytium (cell fusion). Antibodies to S protein can prevent viral entry as well as target the virus for further immune action.
The S477N mutation has been reported to increase binding to human ACE2.
| Target | Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Spike Protein RBD (S477N Mutation) |
| Target Modification | Ser477Asn |
| Modification | Mutation |
| Origin | Virus |
| Expression | Recombinant |
| Host | Mammalian cells |
| Recommended dilutions | Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Form | Lyophilized |
| Purity | > 90% (SDS-PAGE) |
| Reconstitution | Reconstitute in ddH2O to a concentration of 1 mg/ml. |
| Storage | Store between -20 °C and -80 °C. Avoid repeated freeze/thaw cycles. |
| NCBI Accession | YP_009724390.1 |
| Molecular Weight | Observed MW: 35 kDa |
| Tag | C-terminal His tag |
| Buffer | Prior to lyophilization: PBS, pH 7.5. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |
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