SARS-CoV-2 Spike Protein RBD (E484K Mutation) | abx620005

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  • SARS-CoV-2 Spike Protein RBD (E484K Mutation)
  • SARS-CoV-2 Spike Protein RBD (E484K Mutation)
£239.94 - £328.52
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Description

SARS-CoV-2 Spike Protein RBD (E484K Mutation). Cat# abx620005. Supplier: abbexa.

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2/COVID-19) Spike Protein Receptor-Binding Domain (RBD) is a recombinant protein expressed in Mammalian cells.

 

The SARS-CoV-2 Spike Protein (S protein) is a viral protein that allows the entry of SARS-CoV-2 into human cells. The protein forms trimers on the viral capsid and binds to human Angiotensin Converting Enzyme 2 (ACE2) located on the cell surface. The protein has a cleavage site between the Spike Protein and S2 subunits that is targeted by the human enzyme Furin, and it may also cause the development of a syncytium (cell fusion). Antibodies to S protein can prevent viral entry as well as target the virus for further immune action.

 

The E484K mutation is present in several variants, including those first identified in South Africa and Brazil. This mutation has been reported to reduce antibody neutralization of the virus.

Target Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Spike Protein RBD (E484K Mutation)
Target Modification Glu484Lys
Modification Mutation
Origin Virus
Expression Recombinant
Host Mammalian cells
Recommended dilutions Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Form Lyophilized
Purity > 90% (SDS-PAGE)
Reconstitution Reconstitute in ddH2O to a concentration of 1 mg/ml.
Storage Store between -20 °C and -80 °C. Avoid repeated freeze/thaw cycles.
NCBI Accession YP_009724390.1
Molecular Weight Observed MW: 35 kDa
Tag C-terminal His tag
Buffer Prior to lyophilization: PBS, pH 7.5.
Availability Shipped within 5-10 working days.
Note This product is for research use only.
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