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SARS-CoV-2 S1 Protein RBD (L452R Mutation) | abx160087
- SKU:
- abx160087
- Availability:
- Usually shipped in 5 working days
- Size:
- 1 mg
Description
SARS-CoV-2 S1 Protein RBD (L452R Mutation). Cat# abx160087. Supplier: abbexa.
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2/COVID-19) Spike S1 Protein Receptor-Binding Domain (RBD) is a recombinant protein expressed in Insect cells.
The SARS-CoV-2 Spike Protein (S protein) is a viral protein that allows the entry of SARS-CoV-2 into human cells. The protein forms trimers on the viral capsid and binds to human Angiotensin Converting Enzyme 2 (ACE2) located on the cell surface. The protein has a cleavage site between the S1 and S2 subunits that is targeted by the human enzyme Furin, and it may also cause the development of a syncytium (cell fusion). Antibodies to S protein can prevent viral entry as well as target the virus for further immune action.
The L452R mutation is present in the B.1.429/B.1.427 (CAL.20C/Epsilon) variants first identified in California, USA.
| Target | Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) S1 Protein RBD (L452R Mutation) |
| Target Modification | Leu452Arg |
| Modification | Mutation |
| Origin | Virus |
| Expression | Recombinant |
| Tested Applications | ELISA, WB |
| Host | Insect |
| Recommended dilutions | Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Form | Liquid |
| Purity | ≥ 90% (SDS-PAGE) |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Molecular Weight | Calculated MW: 26 kDa Observed MW (12% reducing SDS-PAGE): ~28 kDa |
| Sequence Fragment | 319-541 AA. |
| Tag | C-terminal His tag |
| Buffer | PBS, pH 7.4. Does not contain preservatives. |
| Concentration | 2.2 mg/ml |
| Directions for use | Centrifuge before opening to ensure complete recovery of vial contents. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. This product is shipped with dry ice. |
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