Biovision
Recombinant Coronavirus Spike Protein (MERS-CoV S1; 56-295) | P1514
- SKU:
- P1514
- UPC:
- MPN:
- Availability:
- Usually shipped in 5 working days
- Storage Temperature:
- -20°C
- Shipping:
- Gel Pack
- Shelf Life:
- 12 months
Description
MERS-CoV spike protein plays an important role in virus binding and entry, and the development of MERS-CoV entry/fusion inhibitors targeting the S1 subunit, particularly the receptor-binding domain, and the S2 subunit, especially the HR1 region, of the MERS-CoV spike protein. Spike glycoprotein cleaved into three chains: S1, S2’ and S2. S1 attaches the virion to the cell membrane by interacting with host receptor, initiating the infection. S2’ acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis. S2 mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.
Biovision | P1514 | Recombinant Coronavirus Spike Protein (MERS-CoV S1; 56-295) DataSheet
Biomolecule/Target :
Synonyms: Spike glycoprotein, S glycoprotein, E2, Peplomer protein
Alternates names: Spike glycoprotein, S glycoprotein, E2, Peplomer protein
Taglines: Glycoprotein that enables viral entry into the host cell
NCBI Gene ID #:
NCBI Gene Symbol: S
Gene Source: Coronavirus
Accession #:
Recombinant: True
Source: E. coli
Purity by SDS-PAGE: >95%
Assay:
Purity:
Assay #2:
Endotoxin Level:
Activity (Specifications/test method):
Biological activity:
Results:
Binding Capacity:
Unit Definition:
Molecular Weight:
Concentration:
Appearance: Sterile Filtered colorless solution
Physical form description: Liquid
Reconstitution Instructions:
Amino acid sequence: aa 56-295 (His tag)
Handling: Centrifuge the vial prior to opening.
Usage: For Research Use Only! Not to be used in humans
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