Recombinant Coronavirus Spike Protein (SARS-CoV S2) | P1519

SARS-CoV is an enveloped, single and positive-stranded RNA virus. Cell entry of severe acute respiratory syndrome coronavirus (SARS-CoV) is mediated by the viral spike (S) protein. The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. For viral entry, the surface unit (S1) of SARS S binds to the cellular receptor angiotensin converting enzyme 2 (ACE2) and the transmembrane unit (S2) then fuses the viral membrane with a host cell membrane. The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity, during infection with SARS-CoV. Because the S protein of SARS-CoV is involved in receptor recognition, as well as virus attachment and entry, it represents one of the most important targets for the development of SARS vaccines and therapeutics.

Biovision | P1519 | Recombinant Coronavirus Spike Protein (SARS-CoV S2) DataSheet

Biomolecule/Target :

Synonyms: Spike glycoprotein, S glycoprotein, E2, Peplomer protein

Alternates names: Spike glycoprotein, S glycoprotein, E2, Peplomer protein

Taglines: Glycoprotein that enables viral entry into the host cell

NCBI Gene ID #:

NCBI Gene Symbol:

Gene Source: Coronavirus

Accession #:

Recombinant: True

Source: E. coli

Purity by SDS-PAGE: >95%

Assay:

Purity:

Assay #2:

Endotoxin Level:

Activity (Specifications/test method):

Biological activity:

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Unit Definition:

Molecular Weight: 37 kDa

Concentration:

Appearance: Sterile Filtered colorless solution

Physical form description: Liquid

Reconstitution Instructions:

Amino acid sequence: aa 1051-1076, 1121-1154, 1162-1190

Handling: Centrifuge the vial prior to opening.

Usage: For Research Use Only! Not to be used in humans