SARS-CoV-2 NSP3 Polyclonal Antibody (2019-nCoV) | E-AB-V1039

SARS-CoV-2 NSP3 Polyclonal Antibody (2019-nCoV) | E-AB-V1039 | Elabscience

Category Type: Polyclonal

Synonyms: Non-structural protein 3, PL2-PRO, Papain-like proteinase, PL-PRO, Replicase polyprotein 1a

Applications: ELISA

Reactivity: SARS-COV2

Host: Rabbit

Isotype: IgG

Concentration: 0.33mg/ml

Purify Method: Produced in rabbits immunized with purified, Recombinant SARS-CoV-2 NSP3 protein

Storage: Store at -20℃. Avoid freeze / thaw cycles.

Buffer: PBS, pH7.4, containing 0.05% proclin300, 50% glycerol.

Dilution: Elisa:1:4000~1:8000

Clone NO: N/A

Conjugation: Unconjugated

Immunogen Cat: N/A

Immunogen : Recombinant SARS-CoV-2 NSP3 (Glu1024-Gln1198)

Background: Responsible for the cleavages located at the N-terminus of the replicase polyprotein. In addition, PL-PRO possesses a deubiquitinating/deISGylating activity and processes both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains from cellular substrates. Participates together with nsp4 in the assembly of virally-induced cytoplasmic double-membrane vesicles necessary for viral replication. Antagonizes innate immune induction of type I interferon by blocking the phosphorylation, dimerization and subsequent nuclear translocation of host IRF3. Prevents also host NF-kappa-B signaling.