Recombinant SARS-CoV-2 NSP3 protein | 763-PKSV030325

Recombinant SARS-CoV-2 NSP3 protein | PKSV030325 | Elabscience.

Synonym: nsp3, PL-PRO, Papain-like proteinase, X domain (Macro domain)

Activity: Test in progress

Protein Construction: Recombinant SARS-CoV-2 NSP3 is produced by E.coli expression system and the target gene encoding Glu1024-Gln1198 is expressed with N-His Tag

Sequence: Glu1024-Gln1198

Fusion tag: N-His

Accession: QHD43415.1

Species: SARS-CoV-2

Expressed Host: E.coli

Shipping Conditions: This product is provided as lyophilized powder which is shipped with ice packs.

Purity: >90% as determined by SDS-PAGE

Endotoxin: Please contact us for more information.

Stability and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Mol Mass: 22.03kDa

AP Mol Mass: N/A

Formulation: Supplied as solution form in PBS, pH7.5 or lyophilized from PBS, pH7.5

Reconstitution: Please refer to the printed manual for detailed information.

Background: The coronaviral proteases, papain-like protease (PLpro) and 3C-like protease (3CLpro) , are attractive antiviral drug targets because they are essential for coronaviral replication. PLpro has the additional function of stripping ubiquitin and ISG15 from host-cell proteins to aid coronaviruses in their evasion of the host innate immune responses. Targeting PLpro with antiviral drugs may have an advantage in not only inhibiting viral replication but also inhibiting the dysregulation of signaling cascades in infected cells that may lead to cell death in surrounding, uninfected cells.